Can an analgesic lower blood pressure?

Q: I was given Fentanyl as an analgesic during a colonoscopy procedure. My blood pressure started out at 149/93 and went as low as 103/69 and finally ended at 124/74. Is this pattern consistent with the use of this drug or could this be a case of white coat syndrome?

A: It is not uncommon for blood pressure to be higher at the beginning of a procedure than at the end. I suspect your blood pressure was lowest when the amount of Fentanyl in your blood was the highest. White coat hypertension refers to the elevation of blood pressure taken at a routine office visit as compared to normal blood pressure readings taken in the home setting.

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